An Educated Goal

The previous post was the beginning of your decision to create your personal goal. A1c is just one component in the anti-diabetic goal.

There is an old theory- called the “thrifty gene” theory. The man who came up with this theory admitted, near the end of his life- that it was nothing more than his own guess. An educated guess. We now have proof that this guess was, in fact, basically true- because the body is trying to do something Mr. Neely could never have imagined.

The problem with the theory? We all have the ability to store excess energy- and we all have the ability to create glucose- and in times of absolute famine- the body will break down muscle tissue if there is not enough fat to use for energy.

The body creates glucose from various substrates- and creates glucose from non-carbohydrate substrates in a process called “gluconeogenesis”.

In the type 2 diabetic- this process is operating at an abnormally high rate.

So, what we have during Type 2 Diabetes is a real conundrum. there is too much glucose in the blood. And there is not enough getting to some cells- and the body is generating more glucose- contributing to even higher levels of blood sugar- and the “diabetic organ damage” as they refer to it- comes from the combination of high blood sugar- and increased ectopic fat deposition. A 1-2 punch on a cellular level.

Then we must consider something called “unexplained weight loss”.

Insulin, Glucose and Weight

Glucose is a sugar released into the bloodstream when you eat and drink. The pancreas makes insulin in response to the higher sugar levels in your blood. The body needs this hormone to release glucose to all its cells. With diabetes, the glucose builds up in your bloodstream. You may lose weight because the body needs an energy source and burns fat and muscle instead.³

https://www.verywellhealth.com/rapid-weight-loss-5101064

The quote above is not the most scientifcally specific description- but it is the most common explanation of the prediabetic/diabetic’s “unexplained weight loss”. The burning of fat as they call it- is likely the very goal of the body- because ectopic fat cells- hypertrophied fat cells- that are damaged and dying are up to 500% larger than normal- and the body’s macrophages have a very difficult time engorging them.

Figure 1 ATMs plasticity in adipose tissue. In lean adipose tissue, anti-inflammatory M2-like macrophages are predominant and maintain homeostasis. In obese adipose tissue, an increase in pro-inflammatory M1 ATMs forms a crown-like structure (CLS) surrounding dead adipocytes. Recent research has uncovered new macrophage subtypes, particularly in CLS.

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1153915/full

Lol- They have found “new” subtypes of immune system regulating cells.

I laugh at this because they most certainly are not new- just unknown to scientists. These are specific to adipose tissue for a reason- The macrophages that come from bone marrow- release proinsulin- which blocks the insulin receptor.

The human body is far more intelligent and regenerative than doctors admit.

I doubt your doctor has any clue as to the fact that your immune system and your fat tissue are working together to decrease the size of the damaged, dead and dying adipocytes that must be cleared to allow for proper fat cell functioning. If they did- they would suggest that you “lose fat” instead of “losing weight”.

The overstuffed fat cells cause hypoxia- and that means lack of oxygen. When cells lack oxygen- they die.

Hypoxia also inhibits adipocyte differentiation from preadipocytes. In addition to stressed adipocytes, hypoxia contributes to immune cell immigration and activation which further aggravates adipose tissue fibrosis. Fibrosis is initiated in response to adipocyte hypertrophy in obesity.

Adipose Tissue Hypoxia in Obesity and Its Impact … – PubMed

The truth about fatty-fat, the root cause of type 2 diabetes is right there in black and white. overstuffed fat cells are called hypertrophied fat cells. The larger they become- the “harder” the body fat becomes- because they die and become fibrotic- and are difficult to clear away- and the blood vessels that bring the oxygen and take away the triglycerides when needed for energy- are simply crushed between obese fat cells and the crown like structures and the dead, hardened unforgiving cells. The blood vessels are being crushed by this condition- and the response is called angiogenesis- the development of new blood vessels.

The inhibiting of differentiation of preadipocytes (immature fat cells- the precursor to mature adipocytes- means that the ability to regenerate fat cells has been seriously impacted. The result is an ever growing population of even larger fat cells- which become damaged faster and become dysfunctional faster, and die faster- exacerbating the problem- resulting in higher levels of blood sugar, higher levels of triglycerides, more inflammation and decrease health- metabolic dysfunctions occur on a cellular basis. Fat- as in in triglycerides is forced into organs- more fat is deposited in cells that are not designed to have excessive amounts of fat in them- excessive ectopic fat deposition occurs at an unprecedented rate.

Yes- this stuff is highly scientific- and somewhat difficult to digest (pun intended) for those of us that have little scientific background.

They say a picture is worth a thousand words.

The medical system is not looking for the answers to the diabetic conundrum- if it were then I would not have had to learn all of this stuff. They are “stuck” on not being able to figure out why some people that appear thin can become diabetic, while some people that are fat do not become diabetic.

Us normal, regular people know- the “skinny-fat” person that is out of shape- he is the one susceptible to becoming diabetic- little muscle mass, and things like smoking- cigarettes- weed- vaping- illicit drug use- excessive alcohol consumption- all contribute to cellular stress and damage in one form or another.

THE POINT:

Not only should the goal of the diabetic be to attain the lowest possible blood glucose levels- he should consider the fact that he needs not only to lose fat- or rather SHRINK HIS OVERSTUFFED FAT CELLS-

He needs to most definitely stop smoking- stop drinking- and MUST go on a KETOGENIC Diet.

There is no other way out of the situation.

There is plenty of proof that the OMAD (or one meal per day) and intermittent fasting will rapidly decrease the amount of insulin secreted- but this is terribly difficult to do, right off the bat.

The person with “fatty-fat” and diabetes has a lot going on- and the Keto diet- a true- honest- whole food- meat and vegetable based diet will do the trick. Another thing one can do- move as much as possible.

The point is simple- we need to help the body do what it is attempting to do- and the body is trying to clear those dead and damaged fat cells. The body is trying to purge the fat from ectopic organ fat deposits. The body is trying to properly regenerate itself- but we keep adding “Insult to Injury”- by eating synthetic- man-made chemical laden, high energy, low nutrient content food.

We are far beyond the image below- the image below is what happens BEFORE prediabetes.

Now that you are slightly more educated than your doctors- it is time to come up with a plan.