Rome was not built in a day.

They say it was burned down in one.

Every day a person with type 2 diabetes allow his blood sugar to remain higher than normal is a day that his body sustains damage.

Every day that this damage occurs- puts that person at higher risk for stroke or heart attack.

I briefly touched on the subject of angiogenesis in the last post- I will clarify that here.

Adipose tissue (AT) is an endocrine organ embedded in a dense vascular network. AT regulates the production of hormones, angiogenic factors, and cytokines. During the development of obesity, AT expands through the increase in fat cell size (hypertrophy) and/or fat cell number (hyperplasia). The plasticity and expansion of AT is related to its angiogenic capacities. Angiogenesis is a tightly orchestrated process, which involves endothelial cell (EC) proliferation, migration, invasion, and new tube formation. The expansion of AT is accelerated by hypoxia, inflammation, and structural remodeling of blood vessels.

https://www.frontiersin.org/articles/10.3389/fphys.2020.624903/full

There is no doubt- when we look at the truth- MOST DIABETICS DIE A VASCULAR DEATH. And then we look at our fat tissue as the endocrine/paracrine organ that it is- and we can see that there is a profound problem. Vascular damage is all around- and the body is “wasting” perfectly good endothelial cells attempting to keep the fat organ alive- while the rest of the vasculature is becoming damaged.

If we decrease the need for angiogenesis in the adipose tissue- which is described as a “dense vascular network”- by shrinking the fat cells- allowing them to release stored fat- in fact learning how to become a catalyst in this process- we decrease the burden of angiogenesis in the adipose tissue- because we decrease the hypoxia- and by doing this- We allow new adipocytes to develop from preadipocytes.

This will happen automatically. If you cause this to happen.

When planning on rebuilding your body- improving your health and expanding the quality of your life- while extending the length of it- you do need to take into consideration many things.

It takes about 10-12 years to go from prediabetic to full-blown type 2 diabetes.

The time to becoming a Type 2 Diabetic is dropping- meaning that the person with prediabetes is NOW rapidly racing to type 2 diabetes at significantly faster pace.

The natural pace to become diabetic from prediabetes- makes absolute sense. And it can be explained. The images and discussion of the inability of a preadipocyte to mature into an adipocyte- “adipogenesis” is halted by hypoxia (among other things). The normal fat cell regeneration (replacement due to normal cell wear and death) happens at a rate of 8-10% per year.

The faster your adipocytes die off, the higher your levels of blood glucose and triglycerides will become.

https://www.frontiersin.org/articles/10.3389/fphys.2020.624903/full

The reality is simple- the diabetic has significantly more going on than merely a high sugar problem. And the use of drugs to solve the blood sugar problem- the drugs that force the glucose into cells- is a bad way to fight the disease. that being said- the diet one chooses plays an important role- and the sleep and exercise habits also can exacerbate negative consequences (lack of sleep and exercise) or exponentially increase the return to health (more rest and more exercise).

Maybe there is an easier way to explain this stuff- but in losing the details about our fat organ issues- we throw the baby away with the bathwater.

The diabetic of today simply cannot afford to follow today’s medical protocols and expect to have a good outcome. The medical treatment and goal of an A1c of 7% is allowing the body to continue to perpetuate disease- and the disease will manifest in other complications and symptoms which are simply unacceptable to those of us that care to think about the future.


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